- SynonymOMG,OMGP
- SourceHuman OMgp, His Tag (OMG-H5228) is expressed from human 293 cells (HEK293). It contains AA Ile 25 - Asn 420 (Accession # AAH18050).Predicted N-terminus: Ile 25Request for sequence
- Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 45.5 kDa. The protein migrates as 90-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- EndotoxinLess than 1.0 EU per μg by the LAL method.
- Purity
>92% as determined by SDS-PAGE.
- Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
- Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
- Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
Human OMgp, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.
- BackgroundOligodendrocyte-myelin glycoprotein (OMG or OMGP), is a cell membrane protein which contains eight LRR (leucine-rich) repeats and one LRRNT domain. OMG / OMGP is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system (CNS). OMG / OMGP play roles in both the developing and adult central nervous system. OMG / OMGP may also be involved in the formation and maintenance of myelin sheaths.
- References
- (1)Mikol D.D., et al., 1990, J. Cell Biol. 110:471-479.
- (2)Mikol D.D., et al., 1988, J. Cell Biol. 106:1273-1279.
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