顶生系统/人粘蛋白-1/MUC-1（24-380）蛋白，Fc标签/100ug/MU1
商品编号：
MU1
品牌：
ACROBiosystems
市场价：
¥28800.00
美元价：
14400.00
产品分类：
人体抗原
公司分类：
human_antigen
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
This product is still under development. Please contact us if you have interest in this product. We will accelerate the development process accordingly and reserve this product for you as request.
- SynonymMucin 1,MUC1,CD227,EMA,H23AG,KL-6,MAM6,MUC-1/SEC,MUC-1/X,MUC1/ZD,PEM,PEMT,PUM,CA 15-3,Episialin
- SourceHuman Mucin-1 (24-380), Fc Tag (MU1-H5254) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Ser 380 (Accession # P15941-1).Predicted N-terminus: Ser 24
- Molecular Characterization
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 60.2 kDa.
- Endotoxin
- Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
- Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
- Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
- BackgroundMucin-1 (MUC1) is also known as Tumor-associated epithelial membrane antigen (EMA), Polymorphic epithelial mucin (PEM), Peanut-reactive urinary mucin (PUM), PEMT, Krebs von den Lungen-6 (KL-6), CD antigen CD227, Episialin, H23AG. MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Except protective function by binding to pathogens, MUC1 also functions in a cell signaling capacity. Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers.
- References
- (1)Gendler SJ., et al., 1990, J. Biol. Chem. 265 (25): 15286-93.
- (2)Hollingsworth MA., et al., 2004, Nat. Rev. Cancer 4 (1): 45-60.
- (3)Moncada DM., et al., 2003, Trends Parasitol 19 (7): 305-311.
- (4)Singh PK., et al., 2006, Trends Cell Biol 16 (9): 467-476.
- (5)Lindén SK., et al., 2009, PLoS Pathog. 5 (10): e1000617.
Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.
品牌介绍
ACROBiosystems 是一个具有全球范围影响力的生物技术领导品牌，其运营包括了位于北美、 欧洲和亚洲的数家公司， 主要为生命科学研究、生物制药与疫病诊断等行业提供产品、技术服务和临床应用等解决方案，同时致力于在蛋白组学、药物发现和细胞治疗等领域推广面向工业化和临床转化的技术和产品。ACROBiosystems 的业务遍及全球50多个国家和地区，并通过在北美、亚洲、欧洲等世界范围的不同时区设立分支机构以服务于当地客户与经销商。
